Born in Arkansas, USA, David Hyndman studied at the University of Colorado, and completed his MA at the University of Idaho. In 1972, he moved to Australia to pursue his PhD at the Department of Anthropology and Sociology at the University of Queensland. His doctoral thesis on the Wopkaimin people of the Ok Tedi area of Papua New Guinea was completed in 1979.
He studied subsistence, ethnotaxonomy, ethnobotany, mining and Indigenous peoples, and biodiversity conservation. He completed several periods of fieldwork in the region from 1973 through the 1980s. He spent a good deal of research on the effects of the Ok Tedi mine on the surrounding area, both socially and environmentally.
From 1989-1992, Hyndman worked with the T'boli people of Mindanao in the southern Phillippines. Hyndman was a lecturer and later a reader at the Department of Anthropology and Sociology at the University of Queensland, from which he retired in 2001, moving to the Canberra region.